I have 6.5" wrists and hunted high and low for my mid-size (37mm) Omega. I'm happy I did! 39mm is too big for me. 45?!? Aye-yi-yi....
As a recovering WIS . . .
I dunno - here is a 45mm PAM 190 on my scrawny 6.5" wrist.
Perfect - anything bigger or with a more complicated dial turns me off.
Save room in the closet for the Modoc.